MANOHARAN, MUTHIAH,RAJEEV, KALLANTHOTTATHIL G.,JAYARAMAN, MUTHUSAMY,BUTLER, DAVID,JUNG, MICHAEL E.
申请号：
CA2760776
公开号：
CA2760776C
申请日:
2010.05.05
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention relates to the field of therapeutic agent delivery using lipidparticles. In particular,the invention provides cationic lipids and lipid particles comprising theselipids with a chemicalformula of(see formula III) or (see formula IV), which areadvantageous for the in vivo delivery of nucleic acids, as well as nucleicacid-lipid particlecompositions suitable for in vivo therapeutic use. Additionally, the inventionprovides methodsof preparing these compositions, as well as methods of introducing nucleicacids into cells usingthese compositions.
