The invention discloses a kind of with what stimulation mammal to the composition of the congenital immunity resistance of pathogen, is related to microbiology, immunology and antimicrobial agents therapeutic field. The compositions and methods of the invention are related to adjusting the congenital immunity in individual lung using small molecule compositions, microorganism infection or intrusion are treated or mitigated with what. Specifically, embodiment of the present invention is related to treatment, inhibition or the method for mitigating microorganism infection in microorganism infection or the individual for having the risk that this infection occurs comprising the step of applying a effective amount of TLR9 and TLR2/6 agonist to the individual.本發明公開了一種用於刺激哺乳動物對病原體的先天免疫抵抗力的組合物，其涉及微生物學、免疫學和抗微生物藥物治療學領域。本發明的組合物和方法涉及使用小分子組合物調節個體肺中的先天免疫，以用於治療或減輕微生物感染或侵入。具體而言，本發明的實施方案涉及在患有微生物感染或有發生這種感染之風險的個體中治療、抑制或減輕微生物感染的方法，其包括向所述個體施用有效量的TLR9和TLR2/6激動劑的步驟。
