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Novel heterocyclideneacetamide derivatives
专利权人:
持田製薬株式会社
发明人:
内田 秀春,小菅 直人,佐藤 勉,堀田 大道,神野 智之,前田 能崇,天野 賢一,赤田 安繁
申请号:
JP2011044360
公开号:
JP5303590B2
申请日:
2011.03.01
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
A compound represented by formula (I'): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; R 1 represents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group, an NO 2 group, or the like; R 2 represents halogen, amino, a hydrocarbon group, an aromatic heterocyclic group, or an oxo group; X 1 represents O, -NR 3 -, or -S(O)r-; X 2 represents a methylene group, O, -NR 3 -, or - S(O)r-; Q' represents a heteroaryl group, a heteroarylalkyl group, a substituted aryl group, or an aralkyl group; Cycle moiety represents an aryl ring or a heteroaryl ring; and the wavy line represents an E-isomer or a Z-isomer), a salt of the compound, or a solvate of the compound or the salt. A pharmaceutical composition and a transient receptor potential type I (TRPV1) receptor antagonist each contain, as an active ingredient, at least one of the compound, a salt of the compound, and a solvate of the compound or the salt.
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