The present invention comprises a method of treatment of an autoimmune disease involving a specific tolerance induction (“STI”) event, wherein the method includes: collecting a first sample from the patient prior to the STI event detecting an STI event or performing a procedure that correlates in time to an STI event collecting a second sample from the patient after the STI event preparing lymphocytes from the first and second samples preparing and sequencing DNA or cDNA from the prepared lymphocytes identifying sequences of prevalent T or B cell receptors (“prevalent receptor sequences”) among the lymphocytes of the second sample selecting a regulatory lymphocyte that carries at least one prevalent receptor sequence, which selected regulatory lymphocyte (i) expresses at least one prevalent receptor sequence or (ii) is generated from an autologous or allogeneic naïve lymphocyte, which naïve lymphocyte is engineered and induced to become a regulatory lymphocyte that expresses at least one prevalent receptor sequence culturing the selected regulatory lymphocyte, thereby generating daughter cells of said regulatory lymphocyte and administering the daughter cells to the patient.
