The present invention relates to a production method of a composition that can prevent, ameliorate, or treat hypersensitivity immune diseases including allergic diseases, and the composition produced by the method. In the method, the plasmacytoid dendritic cells with tolerogenic capacity may be induced from the immature dendritic cells at a high yield using a simple and easy process. The plasmacytoid dendritic cells can effectively prevent, ameliorate or treat the hypersensitivity immune diseases