An ultrasound needle guide system for use with an ultrasound transducer and method of use of the guide system to provide predictable trajectories for puncture devices at various depths. The needle guide system basically consists of a bracket and a needle guide. The bracket is arranged to be releasably secured to the ultrasound transducer. The transducer/bracket assembly is then placed into an isolating sterile cover. The needle guide is arranged to be readily attached, e.g., snap-fit, to the transducer/bracket with the cover interposed therebetween. The needle guide can be provided in various versions for differing puncture device sizes and various entry angles in relation to the transducer. In one embodiment the needle guide is arranged to establish plural predetermined entry angles.
