#$%^&*AU2016203347A120160616.pdf#####Abstract The present invention provides a method and device for non-invasive anatomical and systemic cooling. The method and device provide for cooling of various bodily fluid- containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a 5 coolant into or upon the mucus-containing space or surface. Exposure of such mucus to the dry fluid results in evaporation and cooling of the anatomical feature and/or systemic cooling, as intended. In this fashion, therapeutic hypothermia may be achieved to provide for neuroprotection of various organs after ischemic insult, such the brain after cardiac arrest. 33117 E400 Fig. 2