CHUNG, TSE YU,锺泽裕,鍾澤裕,LIN, NAN HEI,林南海,林南海,LI, FENG YIN,李丰颖,李豐穎,CHEN, HSIN AN,陈信安,陳信安,TZEN, JASON TC,曾志正,曾志正
申请号：
TW102103831
公开号：
TWI583375B
申请日:
2013.01.31
申请国别(地区):
TW
年份:
2017
代理人:
摘要：
The present invention relates to the preparation of transition metal-LSB complexes, which are more effective inhibitors of Na+/K+-ATPase than the naturally isolated forms of LSB and Mg-LSB, and thus may possess great potential to be superior substitutes for cardiac glycosides in the treatment of congestive heart failure.本發明係關於製備丹參酚酸B之新穎過渡金屬離子錯合物(簡稱過渡金屬-LSB)。根據本發明製得之丹參酚酸B過渡金屬離子錯合物,具有與分離自天然之丹參酚酸B鎂鹽(Mg-LSB)類似的安定性且不具有毒性,而其較天然分離的LSB或Mg-LSB,對於Na+/K+-ATPase活性更具有顯著的抑制功效,因此更適合用於取代強心配醣體藥物,來製備充血性心衰竭的治療劑。
