Paul Tempest;Brian L. Hodous;Yuan Cheng;Victor J. Cee;Stuart C. Chaffee;Joseph L. Kim;K;Phillip R. Olivieri;Stephanie D. Geuns-Meyer;Xiaotian Zhu;Vinod F. Patel;Brian K. Albrecht;Steven Bellon;Ning Xi
发明人:
Stephanie D. Geuns-Meyer,Brian L. Hodous,Stuart C. Chaffee,Paul Tempest,Ning Xi,Phillip R. Olivieri,Joseph L. Kim,Steven Bellon,Xiaotian Zhu,Yuan Cheng,Brian K. Albrecht,Vinod F. Patel,Victor J. Cee,K
申请号：
US12952156
公开号：
US08476434B2
申请日:
2010.11.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to chemical compounds having a general formula Iwherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
