Robert C. Cuca;Mitchell Kirschner;Jonathan Bortz;R. Saul Levinson
发明人:
Jonathan Bortz,R. Saul Levinson,Mitchell Kirschner,Robert C. Cuca
申请号：
US13557527
公开号：
US20130172279A1
申请日:
2012.07.25
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A pharmaceutical composition comprises (a) an antibacterial agent in an antibacterially effective amount, illustratively comprising clindamycin or a pharmaceutically acceptable salt or ester thereof； and (b) an antifungal agent in an antifungally effective amount, illustratively comprising butoconazole or a pharmaceutically acceptable salt or ester thereof. The composition is adapted for application in a unit dose amount to a vulvovaginal surface and has at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface. The composition is useful for administration to a vulvovaginal surface to treat a mixed bacterial vaginosis and vulvovaginal candidiasis infection.
