THE PRESENT INVENTION IS A METHODS FOR NEUROPROTECTION, FOR TREATING AN ACUTE NEURODEGENERATIVE DISORDER, FOR TREATING A CHRONIC NEURODEGENERATIVE DISORDER AND / OR FOR PREVENTING NEURON DEATH OR DAMAGE FOLLOWING BRAIN, HEAD AND / OR SPINAL CORD TRAUMA OR INJURY COMPRISING ADMINISTERING TO A SUBJECT IN NEED THEREOF A THERAPEUTICALLY EFFECTIVE AMOUNT OF ONE OR MORE NOVEL BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES OF FORMULA (I) AND FORMULA (II) AS HEREIN DEFINED.