Michael Dockal,Fritz Scheiflinger,Sabine Knappe,Susanne Till,Ton Hai,Paul Sanders,Prasad Dande,Cong Jiang
申请号：
US16456553
公开号：
US20190374568A1
申请日:
2019.06.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides non-anticoagulant sulfated or sulfonated polysaccharides (NASPs), which accelerate the blood clotting process. Also provided are pharmaceutical formulations comprising a NASP of the invention in conjunction with a pharmaceutically acceptable excipient and, in various embodiments, these formulations are unit dosage formulations. The invention provides a NASP formulation, which is orally bioavailable. Also provided are methods for utilizing the compounds and formulations of the invention to promote blood clotting in vivo as therapeutic and prophylactic agents and in vitro as an aid to studies of the blood clotting process.
