The present invention provide the discovery free-fat acid acceptor 1 (FFA1) of relevant method and composition a kind of as therapeutic target the neuron for treating or preventing disease or illness be characterized in that the retinosis of the eyes of angiogenesis or angiosis and/or tumour more generally. Treatment and/or prevention and known FFA1 inhibitor composition, the reagent including small molecule and nucleic acid, description. FFA1 inhibitor for identifying new is also provided.