A multi-cellular lay-up process comprises the steps: (a) forming a core material； (b) forming a capsule material； (c) encapsulating the core with the capsule material； (d) adding the capsule to a substrate； and (e) exposing the capsule to a least one bioactivating agent. The process may include forming a plurality of capsules, and the core may comprise one or more mammalian stem cells, culture cell medium and a hydrogel. Preferably, the step of forming the core comprises combining one or more cells, at least one bioactivating agent, cell culture medium and a hydrogel. The capsule material may comprise a water soluble polymer, a bioactive fibrous component, and a solvent. Two sets of capsules may be deposited in single layers on distinct areas of a tray to form stacks of layers. Hydrophobic capsules (e.g. PTFE) may also be added as a barrier to the two sets of cells. Using another delivery system a bioactive agent A may be irrigated over the first group of capsules, and a bioactive agent B irrigated over the second group (figure 8). The PTFE particles may be removed and culture medium added, to leave two groups of differentially activated cells (figure 11).
