MCHUGH, PATRICK,WINTERS, MICHAEL ALBERT,KONIETZKO, JANELLE
申请号：
CA3074714
公开号：
CA3074714A1
申请日:
2018.09.04
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae to a carrier protein. These process are serotype specific and include acid hydrolysis, addition of sodium chloride to the reductive amination reaction, and addition of sucrose to dissolve polysaccharides. Polysaccharide-protein conjugates prepared using the processes of the invention can be included in multivalent pneumococcal conjugate vaccines.
