An actuator is movable between a first position and a second position to move a drive mechanism between a first configuration and a second configuration relative to a housing. A cartridge assembly configured to be removably coupled to the housing to couple such that the cartridge assembly is coupled to the drive mechanism. A first member of the drive mechanism moves a first member of the cartridge assembly to advance a surgical clip of the cartridge assembly in a distal direction when the drive mechanism is placed in the first configuration. A second member of the drive mechanism moves a second member of the cartridge assembly relative to the clamp mechanism when the drive mechanism is placed in the second configuration to transition the clamp mechanism from a first configuration to a second configuration. The clamp mechanism is configured to clamp the surgical clip when in the second configuration.
