UNIVERSITY OF WASHINGTON;INSTITUTE FOR RESEARCH IN BIOMEDICINE
发明人:
KING, NEIL P.,BAKER, DAVID,NICKERSON, BROOKE,STEWART, LANCE JOSEPH,PEREZ, LAURENT,LANZAVECCHIA, ANTONIO,MARCANDALLI, JESSICA
申请号：
CA3058794
公开号：
CA3058794A1
申请日:
2018.04.03
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides； (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide； wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures； and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
