КОЛКА Джерард Р. (US),КЛЕТЗИН Рольф Ф. (US),ТАНИС Стивен П. (US),ЛАРСЕН Скотт Д. (US)
申请号：
RU2012129931/04
公开号：
RU2012129931A
申请日:
2010.12.15
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method for treating or preventing a neurodegenerative disorder in a patient comprising administering to the patient a compound of formula I: or a pharmaceutically acceptable salt gdekazhdy r and are independently selected from H, halo, aliphatic, and alkoxy, wherein the aliphatic or alkoxy group optionally substituted by 1-3 halogen atoms Ryavlyaetsya H Ryavlyaetsya H, halogen, hydroxy, or optionally substituted aliphatic group, -O-acyl, -O-aroyl, -O-heteroaroyl, -O (SO) NH, -O-CH (R) OC (O ) R, -O-CH (R) OP (O) (oR), -OP (O) (oR), or where each and independently Rneobyazatelno substituted Calkilom each independently is Calkilom, Ctsikloalkilom or phenyl, each of which is optionally substituted, iliRi Rvmeste form oxo Ryavlyaetsya H or optionally substituted Calkilom ikoltso A is phenyl, pyridin-2-yl, pyridin-3-yl or pyridin-4-yl, each substituted Rgruppoy Rgruppoy and in any chemically possible position on the ring A.2. The method of claim 1, wherein the neurodegenerative disorder includes Alzheimers disease, Parkinsons disease, ALS, MS, MCI, or any sochetanie.3. Method according sheet 1 where Ryavlyaetsya H.4. Method according sheet 1 where Ryavlyaetsya H, methyl, methoxy, ethoxy, -O-isopropyl, -CF, -OCHFili -OCF.5. Method according sheet 1 where Ryavlyaetsya H, alkyl, halogen or alkoksi.6. A method according to claim 5, wherein Ryavlyaetsya Calkilom.7. Method according sheet 1, wherein the ring A is phenyl which is substituted Rgruppami r and in any chemically possible position A.8 ring. Method according sheet 1, wherein the ring A is optionally substituted pyridin-2-yl or optionally substituted pyridin-3-yl, any of which is substituted Rgruppami r and in any chemically possible position A.9 ring. A method according to claim 7, wherein the ring A is phenyl, and
