PANICKER, Sandip,PARRY, Graham,STAGLIANO, Nancy E.
申请号：
PE2019000814
公开号：
PE20191031A1
申请日:
2017.10.12
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
It refers to an antibody composed of a heavy chain and a light chain, wherein the heavy chain includes a variable region (VH) and a fixed heavy chain region, while the light chain includes a variable light chain region (VL),Understand that VL is a complementary region (VL) 1, CDR2 of VL and CDR3 of VL (including ID No.1, 2 and 3 respectively)；Human Rights Commission, Human Rights Commission, Human Rights Commission, Human Rights Commission, Human Rights Commission, Human Rights Commission, Human Rights Commission, Human Rights Commission, Human Rights Commission, Human Rights Commission, Human Rights Commission, Human Rights Commission, Human Rights Commission, Human Rights Commission, No. 3 (see sections 4, 5 and 6, respectively). It also refers to a nucleoside that encodes antibodies, a vector and a bone cell including nucleosides, an immune cocci and a drug synthesis including antibodies. The current invention is useful as an anti-c1 antibody (the first part of the supplement), which can regulate the activation of the supplement.Se refiere a un anticuerpo que comprende una cadena pesada y una cadena ligera, en donde la cadena pesada comprende una region variable (VH) y una region constante de cadena pesada, y cadena ligera comprende una region variable de cadena ligera (VL), comprendiendo la VL una region determinante de la complementariedad (CDR) 1 de VL, una CDR2 de VL y una CDR3 de VL (estas comprenden las SEC ID NO: 1, 2 y 3 respectivamente)； y la VH, CDR1 de VH, CDR2 de VH y una CDR3 de VH (estas comprenden las SEC ID NO: 4, 5 y 6 respectivamente). Tambien se refiere a un nucleotido que codifica al anticuerpo, un vector y una celula huesped que comprenden al nucleotido, y un inmunoconjugado y una composicion farmaceutica que comprenden al anticuerpo. La presente invencion es util como anticuerpo anti-C1 (primer componente del complemento) para modular la activacion del complemento.
