PROBLEM TO BE SOLVED: To provide an immunotherapy, and molecules and cells for use in the immunotherapy.SOLUTION: A cancer immunotherapy is disclosed. Further, tumor-related T-helper cell peptide epitopes alone that work as active pharmaceutical components of a vaccine composition stimulating anti-tumor immune response, or a combination of them with other tumor-related peptides, are disclosed. In particular, 49 kinds of new peptide sequences derived from HLA class-II molecules of human tumor-related cell lines, usable in a vaccine composition inducing anti-tumor immune response, are disclosed.