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Methods for Administration and Methods for Treating Cardiovascular Diseases with Resiniferatoxin
专利权人:
Board of Regents of the University of Nebraska
发明人:
Irving H. Zucker,Hanjun Wang
申请号:
US16911070
公开号:
US20200323771A1
申请日:
2020.06.24
申请国别(地区):
US
年份:
2020
代理人:
摘要:
There is disclosed a method for administration of a formulation of resiniferatoxin (RTX) to provide cardiac sympathetic afferent denervation when applied in an amount and concentration sufficient to chemically denervate vanilloid 1 receptor (TRPV1)-expressing CSAR (cardiac sympathetic afferent reflex) afferents. There is further disclosed a method for treating heart failure or hypertension and its related indications selected from the group consisting of increased sympatho-excitation, cardiac hypertrophy, increased left ventricular end diastolic pressure (LVEDP), lung edema, and combinations thereof, comprising administering an effective amount of RTX directly to a tissue site selected from the group consisting of epicardium, a T1-T4 dorsal root ganglion and intrathecally to the T1-T4 region of the spinal column.
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