DEGRADATION DE LA KINASE 4/6 CYCLINE-DEPENDANTE (CDK4/6) PAR CONJUGAISON D'INHIBITEURS DE CDK4/6 AVEC UN LIGAND DE TYPE LIGASE E3 ET LEURS PROCEDES D'UTILISATION
The present application provides bifunctional compounds of Formula (I), orTargeting Ligand, or a pharmaceuticallyacceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof,which act as protein degradation inducing moieties forcyclin-dependent kinase 4 (CDK4) and/or cyclin-dependent kinase 6 (CDK6) Thepresent application also relates to methods for thetargeted degradation of CDK4 and/or CDK6 through the use of the bifunctionalcompounds that link a ubiquitin ligase-binding moietyto a ligand that is capable of binding to CDK4 and/or CDK6 which can beutilized in the treatment of disorders modulated by CDK4and/or CDK6
