The invention relates to a formulation and method for activating genes that regulate natural interactions between plants and the environment, based on poly A - D - glucosamine, the derivatives thereof and/or salts of same, as well as organic acids that are precursors of elements for the synthesis of compounds required for the functioning of the activated natural processes. The formulation comprises: (a) poly A - D - glucosamine, the derivatives thereof and/or one of the salts of same, with a viscosity of between 10 cps and 190 cps and with a degree of deacetylation of between 60% and 90% (b) 0.2 % to 12 % v/v of an organic acid solution and (c) an effective quantity in each treated plant of poly - D - glucosamine, the derivatives thereof and salts of same, in the range of 50 ppm to 1.000 ppm, in which the pH of said formulation is between 5.0 and 7.0. The method for activating genes that regulate interactions between plants and the environment, consists in applying a solution to the roots and/or the foliar portion of the plants, one time or multiple times depending on the species and the phenological state thereof, said solution being based on poly A - D - glucosamine, the derivatives thereof and/or salts of same, as well as organic acids that are precursors of elements for the synthesis of compounds required for the functioning of the activated natural processes, at a concentration of between 50 ppm and 1,000 ppm per treated plant, according to the aforementioned formulation.Una formulación y procedimiento para activar los genes que regulan las interacciones naturales entre los vegetales y su medio ambiente, en base a poli A - D - glucosamina, sus derivados y/o sus sales y ácidos orgánicos precursores de elementos para la síntesis de compuestos necesarios para el funcionamiento de los procesos naturales activados, porque comprende: a) poli A - D - glucosamina, sus derivados y/o alguna de sus sales, con una viscosidad comprendida entre 10 cps a 190 cps y con un grad
