Pentacyclic triterpene compounds are provided herein. Also provided are pharmaceutical formulations containing a therapeutically effective amount of one or more of the compounds or pharmaceutically acceptable salts or prodrugs thereof in combination with one or more pharmaceutically acceptable excipients. The pharmaceutical formulations can be administered to a pre obese obese or morbidly obese patient to induce weight loss reduce body fat reduce food intake improve glucose homeostasis prevent obesity or a combination thereof. The compounds can also be co administered with leptin or a leptin analog.
