The Board of Regents of The University of Texas System
发明人:
Jerry W. Shay,Sergei M. Gryaznov
申请号：
US14247967
公开号：
US10463685B2
申请日:
2014.04.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods for treating a telomerase-expressing cell characterized by an over-activation of telomerase in a subject in need thereof comprising administering a pharmaceutical composition comprising a first amount of a 6-mercaptopurine analog, and a second amount of a telomerase inhibitor, wherein the first amount and the second amount together comprises an amount effective to reduce stability of telomere length and to induce cell death in the telomerase-expressing cell are provided. The methods can be used to treat patients with lung cancer, colon cancer, or cervical cancer.
