A device for resecting a femur includes a resection body provided with resection grooves configured to receive a cutting surgical instrument to obtain at least two sections of the femur. The resection body has two separate elements, selectively assembleable to each other in a stable and releasable manner. A first element is a cutting template, having the resection grooves. A second element is a measuring and reference member, having a plurality of measuring and reference holes configured to determine an angular offsetting with respect to a longitudinal axis of the femur, and an axial translation along the longitudinal axis of the femur between the two sections. A releasable holder is provided between the cutting template and the measuring and reference member. The measuring and reference holes are made on the measuring and reference member according to a matrix associated with axial and angular coordinates in ordered rows and columns.