RURAL DEVELOPMENT ADMINISTRATION);대한민국(농촌진흥청장);CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION;REPUBLIC OF KOREA(MANAGEMENT;가톨릭대학교산학협력단;REPUBLIC OF KOREA(MANAGEMENT:RURAL DEVELOPMENT ADMINISTRATION)
发明人:
KIM, Sun Lim,김선림,KWON, Young Up,권영업,PARK, Yong Il,박용일,CHOI, Doo Jin,최두진,JUNG, Gun Ho,정건호,KIM, Mi Jung,김미정,LEE, Yu Young,이유영,KIM, Kee Jong,김기종,SON, Beom Young,손범영,LEE, Jin Seok,이진석,KIM, Jung Tae,김정태,BA
申请号：
KRKR2014/009632
公开号：
WO2015/072667A1
申请日:
2014.10.14
申请国别(地区):
KR
年份:
2015
代理人:
摘要：
The present invention relates to a composition for alleviating oxidative stress-induced cranial nervous system diseases, containing corn silk-derived maysin as an active ingredient and, more particularly, to a pharmacological composition for alleviating degenerative cranial nervous system diseases, wherein maysin increases the expression of mRNAs of antioxidant enzymes (catalase, glutathione peroxidase-1, superoxide dismutases 1 and 2, and heme oxygenase-1), thereby decreasing oxidative stress, and ultimately, inhibiting or blocking nerve cell apoptosis caused by oxidative stress.La présente invention concerne une composition destinée à atténuer les maladies du système nerveux crânien induites par un stress oxydatif, contenant de la maysine dérivée de soie de maïs comme ingrédient actif, et plus particulièrement, une composition pharmacologique destinée à atténuer les maladies du système nerveux crânien dégénératives, la maysine augmentant l'expression des ARNm d'enzymes antioxydantes (catalase, glutathion peroxydase-1, superoxyde dismutases 1 et 2 et hème oxygénase-1), en réduisant ainsi le stress oxydatif et en inhibant ou en bloquant finalement l'apoptose des cellules nerveuse provoquée par le stress oxydatif.본 발명은 옥수수수염 유래 메이신을 유효성분으로 포함하는 산화적스트레스로 인한 퇴행성 뇌신경계 질환 개선용 조성물에 관한 것으로, 보다 구체적으로는 메이신이 산화스트레스에 의한 신경세포사멸을 항산화효소들 (catalase, glutathione peroxidase-1, superoxide dismutase-1,2, heme oxygenase-1)의 mRNA 발현을 증가시켜 산화스트레스를 감소시켜주어, 궁극적으로 신경세포의 세포사멸 (apoptosis)을 억제 또는 차단함으로써 퇴행성 뇌신경계 질환 개선용 약리적 조성물을 발명한 것이다.
