GYEONGGI INSTITUTE OF SCIENCE & TECHNOLOGY PROMOTION
发明人:
OH, JOA SUBKR,오좌섭,AHN, EUN KYUNGKR,안은경,HONG, SEOUG SUKR,홍성수,CHO, YOUNG RAKKR,조영락
申请号：
KR1020150101578
公开号：
KR1020170010249A
申请日:
2015.07.17
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
Disclosed in the present invention is a composition for inhibiting angiogenesis using extracts of zizania latifolia. The composition for inhibiting the angiogenesis inhibits proliferation of human umbilical vein endothelial cells as well as an attachment and a movement thereof. Furthermore, the composition for inhibiting the angiogenesis has the activity of increasing an expression of a p27 which is an inhibitor of a cell cycle and also has the activity of inhibiting the expression of a cyclin E and a cdk2 which involve in a transition from G1 phase to S phase in the cell cycle.COPYRIGHT KIPO 2017본 발명은 혈관내피세포(Human Umbilical Vein Endothelial Cells)의 증식을 억제함과 아울러 그 부착과 이동을 억제하고 cell cycle의 inhibitor인 p27의 발현을 증가시키며 cell cycle에서 G1 phase의 S phase로의 transition에 관여하는 cyclin E 및 cdk2의 발현을 억제하는 등의 활성을 가지는 줄풀 추출물을 이용한 혈관 신생 억제용 조성물을 개시한다.
