A portable and highly automated apparatus and method for introducing at least one compound within erythrocytes； the apparatus comprises a reusable part provided with mechanical elements such as pumps and valves and electronic units such as a control unit； the apparatus also comprises a disposable part, which is adapted to come into contact with the sample containing the erythrocytes and is provided with a system of tubes made of deformable material, a plurality of reservoirs and one or more filters； the apparatus allows a further concentration of the erythrocytes after they have been treated； the apparatus allows to introduce the compound in the erythrocytes in a virtually totally automated manner.
