Nanjing Zhongsen Biological Technology Co., Ltd.;Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry
发明人:
Chengzhang Wang,Zhiwen Qi
申请号：
US16695219
公开号：
US20200093783A1
申请日:
2019.11.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention synthesizes a pH respond micelle such as BPAU-NH2-Gal-PTX micelle which is composed of an urushiol hydrophobic alkyl chain through Michael addition. The experimental analysis of cytotoxicity in vitro and in vivo shows that BPAU-NH2-Gal-PTX enters a HepG2 cell through endocytosis mediated by an ASGPR, releases urushiol and paclitaxel through the micelle, and inhibits the proliferation of the cell. A targeted BPAU-NH2-Gal micelle has advantages such as high-efficient uptake, enhanced anti-tumor effect, favorable biocompatibility, etc. The present invention first applies the urushiol borate to a polymeric micelle of paclitaxel in vivo delivery, so that the urushiol and paclitaxel are loaded together on a micelle unit and used for being in combination with an anti-cancer synergistic therapy, which not only provides an idea for functional study of urushiol biochemical anti-tumor material, but also lays a foundation for the practical application of an urushiol medical micelle.
