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COMPOSITIONS INJECTABLES PERMETTANT UNE ADMINISTRATION CONTROLEE D'UN COMPOSE PHARMACOLOGIQUEMENT ACTIF
专利权人:
INC.;IDEXX LABORATORIES
发明人:
申请号:
EP02802160.8
公开号:
EP1446103B1
申请日:
2002.10.18
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmaceutically acceptable water soluble solvent combined together to form an injectable composition. The lipophilic counterion may be a saturated or unsaturated C<;SUB>;8<;/SUB>;-C<;SUB>;22 <;/SUB>;fatty acid, and preferably may be a saturated or unsaturated C<;SUB>;10<;/SUB>;-C<;SUB>;18 <;/SUB>;fatty acid. When injected into a mammal, at least a portion of the composition precipitates and releases the active compound over time. Thus, the composition forms a slowly releasing drug depot of the active compound in the mammal. Therefore, the present invention enables one to provide a controlled dose administration of the active compound for a periods of up to 15 days or even longer. Many compounds can be administered according to the present invention including, but not limited to, tilmicosin, oxytetracycline, metoprolol, fluoxetine, roxithromycin, and turbinafine.
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中国工程科技知识中心
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