Recombinant fusion protein comprising HIV gp120 linked to an enhancing CD4 binding site mAb

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专利权人:

Yongjun Guan

发明人:

Yongjun Guan,George Lewis,Anthony Devico,Mohammad Sajadi,Tongyun Liu,Marzena Pazgier

申请号：

US14649565

公开号：

US09951106B2

申请日:

2013.12.04

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Fusion proteins comprising a portion of the HIV-1 Env protein (gp120 and gp140) and single-chain fragment V regions (ScFv) of an enhancing antibody that exhibits binding specificity for HIV-1 Env protein are disclosed that may serve in immunogenic formulations for vaccination against HIV-1 infection, as well as methods of generating an immune response using the fusion proteins.

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