Eugene T. Michal,Evgenia Mandrusov,Charles D. Claude,Ni Ding,Murthy Simhambhatla,Syed Faiyaz Ahmed Hossainy,Srinivasan Sridharan,Paul Consigny
申请号：
US12632612
公开号：
US08821473B2
申请日:
2009.12.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
