Anti-CD19 heavy chain antibodies (e.g., UniAbsTM) are disclosed, along with methods of making such antibodies, compositions, including pharmaceutical compositions, comprising such antibodies, and their use to treat B cell disorders that are characterized by the expression of CD19.L'invention concerne des anticorps à chaîne lourde anti-CD19 (par exemple, UniAbsTM), ainsi que des procédés de fabrication de tels anticorps, des compositions, y compris des compositions pharmaceutiques, comprenant de tels anticorps, et leur utilisation pour traiter des troubles des lymphocytes B qui sont caractérisés par l'expression de CD19.