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MULTI PLASMID SYSTEM FOR THE PRODUCTION OF ATTENUATED INFLUENZA B VIRUS
专利权人:
发明人:
申请号:
EP15175068.4
公开号:
EP2995678A1
申请日:
2005.05.20
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25°C (and immunogenic compositions comprising the same) is also provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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