The present invention provides a novel bispecific antigen-binding molecule comprising (a) at least one moiety capable of specifically binding to OX40 and (b) at least one moiety capable of specifically binding to tenascin C (TnC), It also relates to methods of making and using such molecules. [Selection diagram] None本発明は、(a)OX40に特異的に結合できる少なくとも1つの部分と(b)テネイシンC(TnC)に特異的に結合できる少なくとも1つの部分とを含む新規の二重特異性抗原結合分子、並びにこのような分子の製造方法及び使用方法に関する。【選択図】なし