A compound having the following general formula (I): ** Formula ** wherein A is -CHR7-, wherein R7 is hydrogen, optionally substituted C1-10 alkyl, optionally substituted C2-10 alkenyl, optionally C2-10 alkynyl substituted, optionally substituted C 1-14 aryl-C 1-10 alkyl, optionally substituted C 1-10 heteroaryl-C 1-10 alkyl, optionally substituted C 3-10 cycloalkyl, C 3-10 heterocycloalkyl-alkyl optionally substituted members, optionally substituted C6-14 aryl, optionally substituted 5-14 member heteroaryl, optionally substituted C3-10 cycloalkyl or optionally substituted 3-10 member heterocycloalkyl； G is -NH-, -NR6-, -O- or -C (R6) 2-, wherein R6 is independently selected from optionally substituted C1-10 alkyl, optionally substituted C2-10 alkenyl and optionally substituted C2-10 alkynyl； R1 is -Ra-R10； wherein Ra is optionally substituted C1-6 alkylene, and R10 is optionally substituted naphthyl or optionally substituted bicyclic fused heteroaryl； R2 is -W21-W22-Rb-R20, where W21 is - (CO) - or - (SO2) -； W22 is an optionally substituted, -O-, -NH- or C1-6 alkylene bond； Rb is an optionally substituted C1-6 alkylene bond or； and R20 is optionally substituted C1-10 alkyl, optionally substituted C2-10 alkenyl, optionally substituted C2-10 alkynyl, optionally substituted C6-14 aryl, optionally substituted 5-14 membered heteroaryl, optionally substituted C3-10 cycloalkyl or 3-heterocycloalkyl -10 optionally substituted members； R3 is optionally substituted C1-10 alkyl, optionally substituted C2-10 alkenyl or optionally substituted C2-10 alkynyl； "optionally substituted" means that a given radical may consist solely of hydrogen substituents through available valences or may additionally comprise one or more substituents other than hydrogen through available valences, and substituents other than hydrogen are selected from the group consisting in -R8, -OH, -OR8, -OC (O) R8, -OC (O) OR8, -COOH, -COOR8, -CONH2, -CONHR8, -CONR8R4, -NH2, -NHR8, - NR8R4, -SH , -SR8, -SO2R8
