The present description relates to agents, methods for growth-factor receptor activation by modulating the G-protein mediated signal transduction pathway. It is provided the use of a modulator which acts on a growth-factor precursor to inhibit the activation of the extracellular domain of a growth-factor receptor for the manufacture of a medicament for the prevention or treatment of cancers which are induced by G-protein mediated signal transduction wherein the medicament comprises the modulator in an amount sufficient to inhibit growth-factor receptor activation, wherein the modulator acts on proHB-EGF.
