LEEUWENBURGH SANDER CORNELIS GERARDUS,DOUGLAS TIMOTHY,JANSEN JOHANNES ARNOLDUS,SKWARCZYNSKA AGATA,MODRZEJEWSKA ZOFIA
申请号：
NL2007179
公开号：
NL2007179C2
申请日:
2011.07.26
申请国别(地区):
NL
年份:
2013
代理人:
摘要：
This invention relates to the temperature-controlled pH dependant in situ formation of biopolymeric gels. More in particular, the invention provides thermogelling systems that can be used, amongst others, for repair and regeneration of hard tissue, such as bone tissue and cartilage, as well as of certain soft tissues. The present inventors have developed new thermogelling systems by adding enzyme alkaline phosphatase solution to thermosensitive solutions of chitosan and beta- glycerophosphate. This approach surprisingly was found to solve shortcomings of the existing systems, in particular of slow or insufficient gelation at body temperature and the lack of a mineral phase within hydrogels.
