Disclosed are diamino bicyclic retigabine analogues of formula (I), salts, solvates and esters thereof, and methods for their preparation. Specific examples of compounds of formula (I) include: N-(5-(4-fluorophenylamino)-1,3-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3,3-dimethylbutanamide N-(1-(4-fluorophenylamino)-4,6-dimethyl-2,3-dihydro-1H-inden-5-yl)-3,3-dimethylbutanamide and Ethyl 1-(4-fluorophenylamino)-2,3-dihydro-1H-inden-5-yl-carbamate. The compounds of formula (I) modulate potassium channels and are useful for treating hyperexcitability of the nervous system such as neuropathic and chronic pain, bipolar disorder, migraine, epilepsy, a seizure or a disorder characterized by a seizure.
