HAN, Cheol Kyu,한철규,AUH, Jin,CHOI, Nam Song,최남송,HAN, Chang Kyun,한창균,KIM, Tae-Jeong,김태정,PAE, Kamsa,배감사,SHIN, Young June,신영준,HAN, Dong-Oh,한동오,AHN, Soon Kil,안순길
申请号：
KRKR2013/004913
公开号：
WO2013/191396A1
申请日:
2013.06.04
申请国别(地区):
WO
年份:
2013
代理人:
摘要：
The present invention relates to a novel compound having the ability to inhibit the 11β-HSD1 enzyme or to a pharmaceutically acceptable salt thereof, to a method for producing same, and to a pharmaceutical composition containing same as an active ingredient. The compound according to the present invention selectively inhibits the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), and can thus be effectively used as a therapeutic agent for treating diseases caused by the excessive activity of 11β-HSD1, e.g. non-insulin dependent (type 2) diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and diseases and conditions brought on by the excessive activity of glucocorticoids.La présente invention concerne un nouveau composé ayant la capacité à inhiber lenzyme 11β-HSD1 ou un sel pharmaceutiquement acceptable de celui-ci, un procédé de production associé, et une composition pharmaceutique contenant celui-ci en tant que principe actif. Le composé selon la présente invention inhibe sélectivement lactivité de la 11β-hydroxystéroïde déshydrogénase de type 1 (11β-HSD1) et peut par conséquent être utilisé efficacement en tant quagent thérapeutique pour le traitement de maladies provoquées par lactivité excessive de 11β-HSD1, par exemple le diabète non insulinodépendant (de type 2), linsulinorésistance, lobésité, des troubles lipidiques, un syndrome métabolique et des maladies et états apportés par lactivité excessive de glucocorticoïdes.본 발명은 11β-HSD1 효소의 억제활성을 갖는 신규한 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물에 관한 것으로, 본 발명에 따른 화합물은 11β-HSD1(11β-Hydroxysteroid dehydrogenase type 1) 활성을 선택적으로 억제함으로 상기 11β-HSD1의 과활성에 의해 유발되는 질환, 예를 들면 인슐린 비의존성 타입 2 당뇨병, 인슐린 내성, 비만, 지질 장애, 대사 증후군, 및 과도한 글루코코르티코이드 작용에 의해 매개되는 질환 및 상태를 치료하기 위한 치료제로서 유용하게 이용될 수 있다.
