BECK, Petra Helga,BROWN, Marc Barry,CLARK, David Edward,COATES, Anthony,DYKE, Hazel Joan,HU, Yanmin,LONDESBROUGH, Derek John,MILLS, Keith,PALLIN, Thomas David,REID, Gary Patrick,STODDART, Gerlinda
申请号：
ES06808472
公开号：
ES2558685T3
申请日:
2006.11.08
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (Ia) or a pharmaceutically acceptable salt and / or solvate thereof ** Formula ** wherein: R 1 represents 3-methylbut-1-yl, 1-methylbenzimidazol-2-yl, cyclopropyl, cyclopropylmethyl, 2 -phenoxyethyl, benzodioxol-5-ylmethyl, 6- methoxypyridin-3-yl, 6-phenoxypyridin-3-yl, 3-hydroxyphenyl, 3-hydroxy-5-methylphenyl, 4-hydroxyphenyl, 4- (2- dimethylaminoethoxy) phenyl, 3-fluoro-4- (4-methylpiperazin-1-yl) phenyl, 4- (pyridin-3-yloxy) phenyl, benzodioxan-2-ylmethyl, 1- benzylpiperidin-4-yl, cyclohexyl, 1,2,3, 4-tetrahydronaphth-1-yl, 1-phenylethyl, 2-phenylethyl, phenyl, 4-iso-propylphenyl, 4- methoxyphenyl, 3-phenoxyphenyl, 4-phenoxyphenyl, benzyl, (2-methylphenyl) methyl, indan-1-yl or indan-2-yl, 3-methoxypropyl, ethoxycarbonylmethyl, 2- (methoxycarbonyl) ethyl, 2- (ethoxycarbonyl) ethyl, 3- (methoxycarbonyl) propyl, 3- (ethoxycarbonyl) propyl, 1- benzylpyrrolidin-3-yl, 1 -methylpiperidin-4-yl, tetrahydrofuran-2-ylmethyl, 2-pyridylmethyl, 5-methylpyrazin-2-ylmethyl, 2- (2- pyridyl) ethyl, 2- (3-pyr idyl) ethyl, 3- (1-pyrrolidin-2-onyl) propyl, 2-methylphenyl, 4- (piperidin-1-yl) phenyl, 4- (3-pyridyl) phenyl, 2- phenylpropyl (S) -indan- 1-yl, (R) -indan-1-yl, 2- (4-chlorophenyl) ethyl, 2- (4-methoxyphenyl) ethyl or 4- (4-fluorophenoxy) phenyl； R2 represents C1-3 alkyl optionally substituted with one or more substituents selected from halo, OH and N (H) R5g； R3c represents OR7a, and R3a, R3b and R3d all represent H； wherein R7a represents, (a) H, (b) C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl (the last three groups being optionally substituted with one or more substituents selected from halo, OH, C1- alkoxy 6, aryl and Het7), (c) C3-10 cycloalkyl, C4-10 cycloalkenyl (the last two groups being optionally substituted with one or more substituents selected from halo, OH,>； = O, C1-6 alkyl, C1- alkoxy 6, aryl and Het8), (d) aryl or (e) Het9, each aryl independently represents a C6-10 carbocyclic aromatic group, a group that may comprise one or two rin
