PROBLEM TO BE SOLVED: To provide a pharmaceutical preparation of R(+)-N-propargyl-1-aminoindan salt having enhanced content uniformity, and to provide a method for producing the composition and a method for using the same.SOLUTION: There are provided the uses of solid pharmaceutical compositions of R(+)-N-propargyl-1-aminoindan salt having certain particle size distributions. In accordance with the invention, milling, as well as other methods, can be used to alter the particle size distribution of the R(+)-N-propargyl-1-aminoindan salt in order to increase content uniformity of drug products, and a mixture of particles is provided in which more than 90% of the total amount by volume of the R(+)-N-propargyl-1-aminoindan salt particles have a size of less than 250 microns.COPYRIGHT: (C)2013,JPO&INPIT【課題】内容物均一性(contentuniformity)が増強されたR(+)-N-プロパルギル-1-アミノインダン塩の医薬製剤、該組成物の製造方法、およびその使用法の提供。【解決手段】特定の粒子サイズ分布を持つ、R(+)-N-プロパルギル-1-アミノインダン塩の固体医薬組成物の利用。すなわち薬剤生成物の内容物均一性を増大させるために、製粉(milling)、ならびにその他の方法を、R(+)-N-プロパルギル-1-アミノインダン塩の粒子サイズ分布を変化させるために使用し、粒子の全量のうち体積で表して90%超が、250ミクロン未満のサイズを有する混合物。【選択図】なし