Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula Z, IX, X, XI, XII, XIII, XIV, XV, XVI, or XVII. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.本文提供了式Z、IX、X、XI、XII、XIII、XIV、XV、XVI或XVII之CYP11B、CYP17及/或CYP21酶之抑制劑。本文亦描述了包括至少一種本文所描述之化合物之醫藥組合物以及本文所描述之化合物或醫藥組合物治療雄激素依賴型疾病、病症及病狀之用途。