#$%^&*AU2015203322B220160929.pdf#####ABSTRACT Compositions and methods for the treatment and prevention of proliferative disorders comprising, inter alia, an anti-CTLA-4 agent, such as ipilimumab or tremelimumab, in combination with other chemotherapeutic agents, such as dasatinib, imatinib, paclitaxel, gemcitabine, cisplatin or etoposide. In particular, a method of treating cancer comprising the administration of an anti-CTLA-4 antibody with gemcitabine.