A method of manufacturing biodegradable materials for filling nasal cavity of the present invention comprises the following steps: a. within a predetermined temperature range, evenly mixing chitosan and the substrate (starch or cellulose) to make a first solution b. adding crosslinking agent in the first solution for crosslinking reaction c. pouring the first solution into the mold d. removing water through freeze-drying process, thereby the biodegradable materials for filling nasal cavity are obtained. The biodegradable materials are filled in patient’s nasal cavity to stop bleeding and avoid a second time injury by removing, because of biodegradable absorption.一種生物可降解之鼻腔填材製造方法,其中包括下列步驟:a.在預定溫度範圍內均勻混合幾丁聚醣及基材(澱粉或甲基纖維素)以形成第一溶液;b.添加交聯劑於第一溶液以進行交聯反應;c.將第一溶液倒入成形模具中;d.進行冷凍乾燥處理以去除水分,進而獲得生物可降解之鼻腔填材;將生物可降解之鼻腔填材填塞於患者鼻腔中,可達到止血效果,並達到可生物降解吸收以避免在取出時造成二度傷害的目的。a‧‧‧步驟a1‧‧‧步驟b‧‧‧步驟c‧‧‧步驟d‧‧‧步驟