DODD AARON,MEISER FELIX,RUSSELL ADRIAN,NORRET MARCK,BOSCH H WILLIAM
申请号：
NZ59597310
公开号：
NZ595973A
申请日:
2010.04.23
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
IP No. 595973 The present disclosure relates to methods for producing particles of a biologically active material using dry milling processes as well as compositions comprising such materials, medicaments produced using said particles and/or compositions, and to use of said medicaments in the treatment of an animal, including man. The method comprises the steps of: dry milling a solid biologically active material, a facilitating agent and a millable grinding matrix in a mill comprising a plurality of milling bodies (such as a ball mill), for a time period sufficient to produce particles of the biologically active material dispersed in an at least partially milled grinding material, wherein the average particle size is equal to or less than 2000nm, as measured on a particle volume basis or a particle number basis, and wherein the composition produced by said method comprises particles of the biologically active compound at or above a volume fraction of 30 v/v%, wherein the total combined amount of biologically active material and grinding matrix in the mill at any given time is selected from the group consisting of: 200 grams, 500 grams, 1 kg, 2kg, 5 kg, 10 kg, 20 kg, 30 kg, 50 kg, 75 kg, 100 kg, 150 kg, 200 kg, 500 kg, 1000 kg, 1500kg and 2000 kg. preferred biologically active materials include: indomethacin, diclofenac, meloxicam, cyclosporin A, progesterone, celecoxib, cilostazol, ciprofloxacin, 2,4-dichlorophenoxyacetic acid, anthraquinone, creatine monohydrate, glyphosate, halusulfuron, mancozeb, metsulfuron, salbutamol, sulphur, tribenuran and estradiol
