The present invention, in one exemplary embodiment, relates a method of manufacturing an animal chew by molding two body portions of a first material each having at least one concave surface and one or more through holes, attaching the two portions together such that the concave surfaces face one another to form a hollow body portion, injecting a second material into the hollow body portion to fill at least a portion of the hollow body and form areas of exposed regions of the second material by filling the one or more through holes. In a second exemplary embodiment, the two portions may have the concave surfaces over-molded with a second material which fills the one or more through holes. In a third exemplary embodiment, a separate shape of a second material may be molded in a configuration having dimensions complementary to the two half portion and holes when the portions are combined.