Willi CAWELLO,Aurelia LAPPERT,Kristina KASSNER,Hans-Michael WOLFF,Walter MÜLLER,Johannes Josef LEONHARD,Marco EMGENBROICH
申请号：
MX2015006357
公开号：
MX354502B
申请日:
2013.11.21
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
The present invention relates to a transdermal therapeutic system, comprising (a) a backing layer, (b) a solvent -based self-adhesive matrix layer containing rotigotine as active ingredient, and (c) a release liner, wherein the self- adhesive matrix layer has a coating weight of about 75-400 g/m2 and comprises a reservoir layer containing about 9-25 wt.-% rotigotine based on the weight of the reservoir layer, a kit comprising two transdermal therapeutic systems of the present invention as well as a method for the preparation of the transdermal therapeutic system of the present invention. In addition, the present invention relates to a transdermal therapeutic system comprising rotigotine as active ingredient for use in the treatment of patients suffering from Parkinsons disease, Parkinsons plus syndrome, depression, fibromyalgia and the restless-legs syndrome and for use in the treatment or prevention of dopaminergic neuron loss or cognitive disorders by transdermal administration of rotigotine once or twice weekly, wherein the transdermal therapeutic system comprises a backing layer, a solvent -based rotigotine containing self-adhesive matrix layer as well as a release liner and is adapted to allow for the transdermal administration of therapeutically effective amounts of rotigotine for at least 3 days.La presente invención se refiere a un sistema terapéutico transdérmico, que comprende (a) una capa de respaldo, (b) una capa de matriz auto-adhesiva basada en solvente que contiene rotigotina como ingrediente activo, y (c) un revestimiento de liberación, en donde la capa de matriz auto-adhesiva tiene un peso de recubrimiento de alrededor de 75-400 g/m2 y comprende una capa de reservorio que contiene alrededor de 9-25% en peso de rotigotina basado en el peso de la capa de reservorio, un kit que comprende dos sistemas terapéuticos transdérmicos de la presente invención así como un método para la preparación del sistema terapéutico transdérmico de la presente invención.
