The present invention relates to an equipment and a process for manufacturing orthodontic and/or prosthetic dental devices. The equipment (10) for manufacturing orthodontic or prosthetic dental devices comprises a plurality of working stations (11-18) adapted to carry out at least one working operation on an orthodontic or prosthetic semi-finished product and/or on a positive model of a dental arch, at least one working station (12) of the plurality of working stations (11-18) being a prototyping station (12) and being adapted to carry out prototyping of the orthodontic or prosthetic semi¬finished product and/or of the positive model by means of one or more mechanical subtractive or additive working operations; a grasping device (20) adapted to maintain the orthodontic or prosthetic semi-finished product and/or the positive model grasped in particular during the working operations, and to move it between a plurality of working stations (11-18); and a processing unit (19) adapted to drive the plurality of working stations (11-18) and the grasping device (20) maintaining updated information about position and orientation of the orthodontic or prosthetic semi-finished product and/or of the positive model thanks to the grasping device (20); the prototyping station (12) is adapted to carry out one or more subtractive or additive mechanical working operations while the orthodontic or prosthetic semi-finished product and/or the positive model is grasped by the grasping device (20).